Description

1-(3,5-Bis(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroethanone is a high-value fluorinated aromatic ketone building block, prized for its unique electronic and steric properties imparted by the trifluoromethyl groups. This compound is essential for introducing the highly lipophilic and electron-withdrawing 3,5-bis(trifluoromethyl)phenyl moiety into complex molecular architectures. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for applications in catalysis, ligand synthesis, and as a key intermediate in the development of active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance biological activity, stability, and lipophilicity.
• Catalyst & Ligand Development: Serves as a key building block for creating sophisticated organometallic catalysts and chiral ligands used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modulate electronic properties.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships and introducing fluorine atoms into complex molecules in academic and industrial R&D settings.

Basic Information

Product Name	1-(3,5-Bis(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroethanone
CAS No.	130336-17-3
Molecular Formula	C10H3F9O
Molecular Weight	310.12 g/mol
Synonyms	3,5-Bis(trifluoromethyl)phenacyl trifluoride; 2,2,2-Trifluoro-1-[3,5-bis(trifluoromethyl)phenyl]ethanone; 1-[3,5-Bis(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one; α,α,α-Trifluoro-3',5'-bis(trifluoromethyl)acetophenone; 3',5'-Bis(trifluoromethyl)-2,2,2-trifluoroacetophenone; TFAP; BTFP-TF Ketone
EINECS	Contact for details

Quality Control

Our production of 1-(3,5-Bis(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We operate under a quality system aligned with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of reactive carbonyl and fluoride groups, store separately from strong bases, reducing agents, and moisture-sensitive materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.