Description

Hemoglobin Birmingham CAS NO 130299-53-5 is a specific, naturally occurring variant of human hemoglobin, characterized by a point mutation that alters its oxygen-binding properties. This compound is of significant value in biochemical and clinical research for studying hemoglobinopathies, oxygen transport dynamics, and the structure-function relationships of mutant hemoglobins. It is primarily needed by research institutions, diagnostic laboratories, and pharmaceutical developers focused on hematological disorders, blood substitute technologies, and advanced biosensor development.

Application

• Biochemical Research Standard: Used as a reference material in studies of hemoglobin structure, function, and stability.
• Clinical Diagnostics Development: Serves as a critical component in the development and calibration of assays for detecting hemoglobin variants.
• Hematology Studies: Employed in research investigating the pathophysiology of specific hemoglobinopathies and their impact on erythrocyte function.
• Oxygen Carrier Research: Utilized in the development and testing of novel blood substitutes and oxygen-therapeutic agents.
• Educational & Reference Material: Supplied to academic and teaching laboratories for advanced coursework in biochemistry and molecular medicine.
• Biosensor Calibration: Acts as a calibrant in the development of optical or electrochemical sensors designed to measure blood oxygen parameters.

Basic Information

Product Name	Hemoglobin Birmingham
CAS No.	130299-53-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hb Birmingham; Hemoglobin variant Birmingham; Hemoglobin B; Unstable hemoglobin Birmingham; Hemoglobin α2β2 144(HC1) Lys→Asn; HBB: c.434A>C (p.Lys145Thr)
EINECS	Contact for details

Quality Control

Our Hemoglobin Birmingham is produced and handled under strict quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is characterized using advanced analytical techniques, including electrophoresis and spectrophotometry, to confirm identity and assess stability. A comprehensive Certificate of Analysis (COA) detailing purity, physical form, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider keeping the container under inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (Electrophoresis)	Conforms to standard for Hb Birmingham
Purity (by HPLC)	≥ 90% (Hb Birmingham)
Protein Content (Biuret)	≥ 95%
Methemoglobin Content	≤ 5%
Solubility	Clear, red solution in buffer
Biological Activity (O2 Binding)	Altered vs. HbA (Contact for data)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.