Description

Secobarbital-D5 is a deuterated internal standard of the barbiturate derivative secobarbital, specifically labeled with five deuterium atoms. This compound is essential for ensuring analytical accuracy and reliability in quantitative mass spectrometry, providing a stable isotopic reference for method development and validation. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors who require precise and reproducible analytical results.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of secobarbital and related compounds.
• Forensic Toxicology: Enables accurate quantification of secobarbital in biological matrices (e.g., blood, urine) for drug testing and post-mortem investigations.
• Pharmaceutical R&D: Supports pharmacokinetic studies, metabolism research, and stability testing of barbiturate-based drug formulations.
• Clinical Diagnostics: Used in developing and validating assays for therapeutic drug monitoring (TDM) in patient samples.
• Method Development & Validation: Critical for establishing and verifying the accuracy, precision, and linearity of new analytical methods.
• Regulatory Compliance Testing: Facilitates testing in compliance with standards from agencies like the FDA and EMA for drug safety and efficacy.

Basic Information

Product Name	Secobarbital-D5
CAS No.	130221-73-7
Molecular Formula	C12H13D5N2O3
Molecular Weight	243.31 g/mol
Synonyms	5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-1,3-d2,5-d3; Deuterated Secobarbital; Secobarbital-d5; Secobarbital (methyl-d3, allyl-d2); 5-(2-Propen-1,1-d2-yl)-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-1,3-d2
EINECS	Contact for details

Quality Control

Our Secobarbital-D5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.