Description

Gastrin Releasing Peptide (21-27), Glu(21)-Phe(22)- is a bioactive peptide fragment derived from the C-terminus of the gastrin-releasing peptide (GRP). This compound is of significant value for its role in neurobiological and oncological research, specifically as a ligand for the bombesin receptor subtype 2 (BB2). It is primarily needed by pharmaceutical research institutions, biotechnology companies, and academic laboratories engaged in the study of cancer diagnostics, neuropeptide signaling pathways, and the development of targeted therapeutic agents.

Application

• Biomedical Research: Used as a key reagent in studies investigating the role of GRP and bombesin receptors in various physiological and pathological processes.
• Cancer Research: Employed in the development and evaluation of diagnostic imaging agents and targeted therapies for cancers expressing bombesin receptors, such as prostate, breast, and small-cell lung cancer.
• Neuroscience Studies: Applied in research on central nervous system functions, including the regulation of feeding behavior, stress responses, and memory.
• Receptor Binding Assays: Serves as a standard or competitor in competitive binding assays to characterize receptor affinity and specificity.
• Peptide Chemistry & Conjugation: Acts as a starting material or model compound for the synthesis of peptide-drug conjugates or radiolabeled analogs for diagnostic purposes.
• In vitro & In vivo Models: Utilized in cell-based assays and animal models to study tumor targeting and the pharmacokinetics of receptor-targeting compounds.

Basic Information

Product Name	Gastrin Releasing Peptide (21-27), Glu(21)-Phe(22)-
CAS No.	130192-64-2
Molecular Formula	C41H58N10O12
Molecular Weight	882.97 g/mol
Synonyms	GRP (21-27); Gastrin-Releasing Peptide Fragment 21-27; Glu-Trp-Ala-Val-Gly-His-Leu-NH2; pGlu-His-Trp-Ala-Val-Gly-His-Leu-NH2 (fragment 21-27); Bombesin Receptor Agonist (BB2); Neuromedin C (fragment); GRP-21-27; BB2 Receptor Ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Gastrin Releasing Peptide (21-27), Glu(21)-Phe(22)- is characterized using advanced analytical techniques to guarantee identity, purity, and biological activity. Certificates of Analysis (COA) detailing purity by HPLC, peptide content, amino acid analysis, and mass spectrometry (MS) data are available upon request. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.