Description

n-(2,4-Difluorophenyl)-2-Hydroxy-3-Pyridine-Carboxamide is a specialized heterocyclic compound featuring a pyridine-carboxamide core substituted with difluorophenyl and hydroxyl groups. This molecular architecture makes it a valuable key intermediate and building block in advanced organic synthesis, particularly for the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Research: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluorophenyl and hydroxypyridine motifs.
• Chemical Synthesis Reagent: Used in academic and industrial research laboratories for constructing complex heterocyclic systems and studying structure-activity relationships (SAR).
• Material Science Precursor: Potential use in the synthesis of specialized ligands for catalysis or functional materials, given its chelating properties.

Basic Information

Product Name	n-(2,4-Difluorophenyl)-2-Hydroxy-3-Pyridine-Carboxamide
CAS No.	130191-66-1
Molecular Formula	C12H8F2N2O2
Molecular Weight	250.20 g/mol
Synonyms	2-Hydroxy-N-(2,4-difluorophenyl)nicotinamide; 2-Hydroxy-N-(2,4-difluorophenyl)-3-pyridinecarboxamide; 3-Pyridinecarboxamide, N-(2,4-difluorophenyl)-2-hydroxy-; Nicotinamide, 2-hydroxy-N-(2,4-difluorophenyl)-; 130191-66-1; 2-Hydroxy-N-(2,4-difluorophenyl)pyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our n-(2,4-Difluorophenyl)-2-Hydroxy-3-Pyridine-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.