Description

Interleukin-10 is a pleiotropic cytokine with potent anti-inflammatory and immunosuppressive properties. Its primary value lies in modulating immune responses, making it a critical research tool and a potential therapeutic agent. This high-purity cytokine is essential for researchers and developers in the fields of immunology, oncology, and autoimmune disease research. The product is supplied as a lyophilized powder, ensuring stability and ease of reconstitution for laboratory use.

Application

• Immunological Research: Fundamental studies of immune regulation, T-cell and B-cell function, and macrophage polarization.
• Inflammation Models: Used in vitro and in vivo to suppress pro-inflammatory cytokine production and study anti-inflammatory pathways.
• Cell Culture Supplement: Added to media for the expansion and differentiation of specific immune cell populations, such as regulatory T cells (Tregs).
• Therapeutic Development: Serves as a reference standard or active pharmaceutical ingredient (API) in pre-clinical development for autoimmune and chronic inflammatory diseases.
• Diagnostic Assay Development: Used as a calibration standard in ELISA kits and other immunoassays to quantify IL-10 levels in biological samples.
• Oncology Research: Investigation of the tumor microenvironment, where IL-10 plays a complex role in cancer immunology.

Basic Information

Product Name	Interleukin-10
CAS No.	130068-27-8
Molecular Formula	C600H950N160O190S10 (Approximate, for human IL-10 monomer)
Molecular Weight	~18.5 kDa (Approximate, glycosylated form)
Synonyms	IL-10; IL10; Cytokine Synthesis Inhibitory Factor (CSIF); Human Interleukin-10; TGIF; M-DCGF; B-TCGF; B-cell-derived T-cell growth factor; Tenovin
EINECS	Contact for details

Quality Control

Our Interleukin-10 is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, HPLC, and mass spectrometry, to confirm identity and purity exceeding 95%. Biological activity is validated using cell-based bioassays. A comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, sterility, and specific activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. Once reconstituted, aliquot and store at -70°C to -80°C to prevent loss of activity. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE & HPLC)	> 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by cell proliferation/inhibition assay
Reconstitution	Sterile-filtered water or buffer specified on COA
Sterility	Sterile-filtered (0.2 µm)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.