Description

Ercc-2 Protein CAS NO 130067-74-2 is a highly purified, recombinant protein critical for DNA excision repair and genomic stability research. Its primary value lies in its role as a key component of the nucleotide excision repair (NER) complex, essential for studies in molecular biology, toxicology, and cancer research. This protein is indispensable for pharmaceutical R&D, academic institutions, and diagnostic kit manufacturers focused on understanding DNA damage response mechanisms and developing related therapeutics.

Application

• Biochemical Research: Used as a critical reagent in in vitro assays to study the mechanism of nucleotide excision repair (NER).
• Drug Discovery & Screening: Employed in high-throughput screening platforms to identify novel compounds that modulate DNA repair pathways for oncology targets.
• Diagnostic Development: Serves as a standard or control protein in the development of ELISA kits and other immunoassays for DNA damage biomarkers.
• Academic Research: Fundamental tool for investigating the molecular basis of genetic disorders linked to NER deficiencies, such as Xeroderma Pigmentosum.
• Toxicology Studies: Used to assess the genotoxic potential of chemicals by evaluating their impact on the NER pathway activity.
• Protein-Protein Interaction Studies: Essential for mapping interactions within the DNA repair machinery using techniques like pull-down assays or surface plasmon resonance (SPR).

Basic Information

Product Name	Ercc-2 Protein
CAS No.	130067-74-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ERCC2 Protein; Excision Repair Cross-Complementation Group 2 Protein; XPD Protein; Xeroderma Pigmentosum group D-complementing protein; TFIIH basal transcription factor complex helicase subunit XPD; RAD3 homolog; ERCC2/XPD; DNA repair protein complementing XP-D cells
EINECS	Contact for details

Quality Control

Our Ercc-2 Protein is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, identity confirmation by mass spectrometry, and functional activity assays. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Mass Spec)	Conforms
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assayed (e.g., ATPase/DNA helicase activity)
Solubility	Reconstitutes in suitable buffer (e.g., Tris-HCl, pH 8.0)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.