Description

3,3-Difluoro-2,2-Dimethylbutanoic Acid is a high-purity fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the gem-difluoro and quaternary carbon groups adjacent to the carboxylic acid functionality, enabling precise structural modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate for developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or modifier for creating specialty polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the preparation of chiral auxiliaries and complex ligands for asymmetric catalysis.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on reaction pathways and molecular properties in medicinal chemistry.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation.

Basic Information

Product Name	3,3-Difluoro-2,2-Dimethylbutanoic Acid
CAS No.	130021-54-4
Molecular Formula	C6H10F2O2
Molecular Weight	164.14 g/mol
Synonyms	3,3-Difluoro-2,2-dimethylbutyric Acid; 2,2-Dimethyl-3,3-difluorobutanoic Acid; Butanoic acid, 3,3-difluoro-2,2-dimethyl-; DFDMBA; α,α-Dimethyl-β,β-difluorobutyric Acid
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-2,2-Dimethylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container must be kept tightly sealed due to the compound's nature as a strong acid/organic solvent.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.