Description

Boc-L-Ala-Nitrile CAS NO 130013-83-1 is a protected amino acid derivative where the α-amino group of L-alanine is safeguarded by a tert-butoxycarbonyl (Boc) group and the carboxylic acid is converted to a nitrile. This compound is a crucial chiral building block in organic synthesis, valued for its role in constructing complex peptide mimetics and other bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the synthesis of novel compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to introduce the alanine backbone with a nitrile "warhead" or bioisostere in drug discovery programs targeting enzymes.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected amino acid derivative for the controlled assembly of specialized peptide sequences.
• Agrochemical Synthesis: Acts as a building block for creating chiral active ingredients with specific biological activity.
• Chemical Biology Probes: Utilized in the development of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Academic & Contract Research: A valuable reagent for methodological development in asymmetric synthesis and organocatalysis research.

Basic Information

Product Name	Boc-L-Ala-Nitrile
CAS No.	130013-83-1
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]propanenitrile; N-(tert-Butoxycarbonyl)-L-alanine nitrile; Boc-L-alanine nitrile; Boc-L-Ala-CN; (S)-2-((tert-Butoxycarbonyl)amino)propanenitrile; N-Boc-L-alaninenitrile; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, nitrile
EINECS	Contact for details

Quality Control

Our Boc-L-Ala-Nitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.