Description

Excretory-Secretory Protein 11 Kda, Trichostrongylus Colubriformis is a purified protein antigen derived from the parasitic nematode *Trichostrongylus colubriformis*. This compound is of significant value in veterinary parasitology and immunology research, serving as a critical reagent for the study of host-parasite interactions and the development of diagnostic tools. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies focused on animal health, particularly for ruminants like sheep and goats.

Application

• Veterinary Diagnostic Development: Key antigen for ELISA and other immunoassays to detect *T. colubriformis* infections in livestock.
• Immunological Research: Used to study the host immune response, antibody production, and mechanisms of parasite evasion.
• Vaccine Research & Development: Investigated as a potential vaccine candidate or component to induce protective immunity against trichostrongylosis.
• Parasitology Studies: Essential for in vitro and in vivo studies on parasite biology, excretory-secretory (ES) product function, and pathogenicity.
• Reference Standard: Serves as a purified standard for quality control and calibration in diagnostic and research laboratories.
• Cross-Reactivity Studies: Employed to evaluate antigenic relationships between different nematode species for improved diagnostic specificity.

Basic Information

Product Name	Excretory-Secretory Protein 11 Kda, Trichostrongylus Colubriformis
CAS No.	129978-62-7
Molecular Formula	Contact for details
Molecular Weight	~11 kDa (Approximate)
Synonyms	T. colubriformis ES 11 kDa Protein; Trichostrongylus colubriformis Excretory/Secretory Antigen; 11 kDa Nematode ES Protein; Tc-ES-11; Haemonchus contortus cross-reactive antigen (potential); Small ruminant nematode antigen; Parasitic helminth antigen
EINECS	Contact for details

Quality Control

Our Excretory-Secretory Protein 11 Kda is produced and purified under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity assessment via SDS-PAGE and HPLC, protein concentration verification, and functional validation in immunoassays. Certificates of Analysis (COA) detailing purity, identity, and endotoxin levels are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use in a low-humidity environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single major band at ~11 kDa
Purity (HPLC)	≥ 90%
Protein Content (BCA/Bradford)	≥ 95% of total weight
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (ELISA)	Reactive with specific antisera
Solubility	Soluble in PBS or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.