Description

Gadolinium-1,7,13-Triaza-4,10,16-Trioxacyclooctadecane-N,N',N''-Triacetic Acid CAS NO 129964-84-7 is a highly specific macrocyclic chelating agent designed for complexing gadolinium (III) ions. This compound is critical for creating stable, high-relaxivity contrast agents used in advanced diagnostic imaging. It is primarily required by manufacturers in the pharmaceutical and medical imaging industries for developing next-generation Magnetic Resonance Imaging (MRI) contrast media.

Application

• MRI Contrast Agent Precursor: The primary application is as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of macrocyclic gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging.
• Medical Research & Development: Used in R&D laboratories for developing novel diagnostic imaging agents with improved stability and safety profiles.
• Radiopharmaceutical Synthesis: Serves as a chelator platform for creating targeted imaging agents when conjugated with specific biomolecules.
• In Vitro Diagnostics: Can be utilized in the formulation of contrast solutions for preclinical and cellular imaging studies.
• Material Science Research: Employed in academic and industrial research exploring lanthanide complexes for optical, magnetic, or catalytic applications.

Basic Information

Product Name	Gadolinium-1,7,13-Triaza-4,10,16-Trioxacyclooctadecane-N,N',N''-Triacetic Acid
CAS No.	129964-84-7
Molecular Formula	C21H33GdN3O9
Molecular Weight	Approx. 618.76 g/mol
Synonyms	Gadolinium DO3A; Gd-DO3A; Gadolinium(III) 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid complex (common mis-assignment for triacetate); Gadolinium-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate; HPDO3A-Gd; Macrocyclic Gd-chelate; Gadoterate complex precursor; 1,7,13-Triaza-4,10,16-trioxacyclooctadecane-N,N',N''-triacetic acid, gadolinium complex
EINECS	Contact for details

Quality Control

Our Gadolinium-1,7,13-Triaza-4,10,16-Trioxacyclooctadecane-N,N',N''-Triacetic Acid is manufactured under strict quality control protocols to ensure it meets the exacting standards required for pharmaceutical intermediates. Production adheres to current Good Manufacturing Practice (cGMP) principles where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (Gd Complex)	≥ 98.0% (by HPLC)
Free Gadolinium	≤ 0.1%
Free Ligand	≤ 1.0%
Residual Solvents	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.