Description

125I-Azido-Papa-Apec CAS NO 129932-69-0 is a specialized, radiolabeled chemical probe designed for advanced biochemical and pharmacological research. This compound is critical for studying receptor-ligand interactions and enzyme activity through photoaffinity labeling techniques. It is primarily utilized by research scientists and pharmaceutical developers in the fields of neurochemistry, molecular pharmacology, and radiopharmaceutical discovery.

Application

• Photoaffinity Labeling Studies: Used to covalently tag and identify adenosine receptor subtypes and other protein targets upon UV light activation.
• Biochemical Assay Development: Serves as a key reagent in developing high-throughput screening assays for drug discovery programs.
• Molecular Pharmacology Research: Enables the investigation of ligand binding sites, receptor occupancy, and allosteric modulation mechanisms.
• Radioligand Binding Assays: Acts as a potent tracer for quantifying receptor density and affinity in competitive binding experiments.
• Neurochemical Pathway Analysis: Employed in research focused on purinergic signaling and its role in neurological functions and disorders.
• Radiopharmaceutical Precursor: Potential use as an intermediate in the synthesis of diagnostic imaging agents for positron emission tomography (PET).

Basic Information

Product Name	125I-Azido-Papa-Apec
CAS No.	129932-69-0
Molecular Formula	C18H21IN8O2
Molecular Weight	508.31 g/mol
Synonyms	N6-(4-Azidophenethyl)adenosine-5'-N-ethyluronamide, iodinated; 125I-Azido-PAPA-APEC; 2-[[4-Azido-3-[125I]iodophenethyl]amino]adenosine-5'-N-ethyluronamide; Iodine-125 labeled Azido-PAPA-APEC; Photoaffinity label for A2A adenosine receptors; 125I-ANAPA; Radioiodinated azidophenethyl derivative of CGS 21680 analog
EINECS	Contact for details

Quality Control

Every batch of 125I-Azido-Papa-Apec is manufactured and controlled under strict quality management systems. The product undergoes comprehensive analytical testing, including HPLC for radiochemical purity and identity confirmation, to ensure it meets the exacting standards required for research use. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, specific activity, and solvent content, is supplied with each order.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term storage, keep at -70°C to -80°C. Allow the vial to reach ambient temperature before opening to minimize condensation. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear to slightly hazy solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	2200 Ci/mmol (81.4 TBq/mmol)
Solvent	Ethanol:Water mixture
Concentration	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.