Description

3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzamide is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique halogenated and trifluoromethylated structure, which imparts desirable electronic and steric properties to target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen substituents.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging reagent in the design of chemical probes and enzyme inhibitors for biological research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated compounds.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzamide
CAS No.	129931-46-0
Molecular Formula	C8H4ClF4NO
Molecular Weight	241.57 g/mol
Synonyms	3-Chloro-2-fluoro-5-(trifluoromethyl)benzamide; 2-Fluoro-3-chloro-5-(trifluoromethyl)benzamide; Benzamide, 3-chloro-2-fluoro-5-(trifluoromethyl)-; 129931-46-0; 3-Chloro-2-fluoro-alpha,alpha,α-trifluoro-p-toluamide
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.