Description

D-Asparagine Methyl Ester Hydrochloride is a high-purity, enantiomerically pure derivative of the amino acid asparagine, specifically formulated as the methyl ester hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and metabolic drugs.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to incorporate D-asparagine residues.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, metabolic pathway research, and as a substrate for asparaginase enzymes.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Prodrug Development: Utilized in the design and synthesis of ester-based prodrugs to enhance the bioavailability or targeting of therapeutic agents.
• Fine Chemical Production: Acts as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Item	Details
Product Name	D-Asparagine Methyl Ester Hydrochloride
CAS No.	129902-07-4
Molecular Formula	C5H11ClN2O3
Molecular Weight	182.60 g/mol
Synonyms	D-Asparagine methyl ester HCl; Methyl (2R)-2-amino-3-carbamoylpropanoate hydrochloride; (R)-2-Amino-3-carbamoylpropionic acid methyl ester hydrochloride; D-Asparagine methyl ester monohydrochloride; Methyl D-asparaginate hydrochloride; (R)-2-Amino-3-carbamoyl-propionic acid methyl ester hydrochloride; D-Asp-NH2-OMe·HCl
EINECS	Contact for details

Quality Control

Our D-Asparagine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.