Description

Pasteurella Multocida Toxin (PMT) is a potent, single-chain protein exotoxin produced by certain strains of the bacterium *Pasteurella multocida*. This biologically active compound is of significant interest in veterinary and biomedical research due to its unique mechanism of action as a mitogenic deamidase, which permanently activates heterotrimeric G proteins. It is primarily utilized as a critical research reagent for studying cellular signaling pathways, bone biology, and for the development of vaccines and diagnostic tools against atrophic rhinitis in swine and other pasteurellosis in animals.

Application

• Veterinary Vaccine Development: Key antigen for creating vaccines against atrophic rhinitis caused by toxigenic *P. multocida* in pigs.
• Biomedical Research: Essential tool for investigating G protein signaling pathways, cellular proliferation, and osteoclast differentiation.
• Diagnostic Reagent Production: Used in ELISA kits and other immunoassays for detecting PMT-specific antibodies in animal sera.
• Toxicology Studies: Serves as a reference standard in studies examining the pathogenesis and host immune response to bacterial toxins.
• Cell Biology & Signal Transduction: Employed to study the deamidation of glutamine residues in GTPases and its downstream effects on cell function.
• Antigen for Antibody Generation: Used to immunize animals for the production of polyclonal or monoclonal antibodies specific to PMT.

Basic Information

Product Name	Pasteurella Multocida Toxin
CAS No.	129876-91-1
Molecular Formula	Contact for details
Molecular Weight	~146 kDa
Synonyms	PMT; Pasteurella Multocida Dermonecrotic Toxin; Pasteurella Toxin; Atrophic Rhinitis Toxin; *Pasteurella multocida* type D toxin; *Pasteurella multocida* mitogenic toxin
EINECS	Contact for details

Quality Control

Our Pasteurella Multocida Toxin is produced and handled under stringent quality management protocols. Each batch is subjected to rigorous purity and activity testing, including SDS-PAGE, Western Blot, and functional cell-based assays to ensure biological potency and specificity. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at ≤ -70°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE/Western Blot)	Corresponds to standard
Purity (SDS-PAGE)	≥ 90%
Protein Content (BCA/Bradford)	≥ 1 mg/vial
Biological Activity (Cell-based assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.