Description

3-tert-Butoxycarbonylamino-3-Methyl-Butyric Acid is a high-purity, protected amino acid derivative widely used as a critical building block in organic synthesis. Its primary value lies in serving as a versatile intermediate for the construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in peptide and peptidomimetic research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the 3-amino-3-methylbutyric acid (Amb) residue with Boc (tert-butoxycarbonyl) protection.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors targeting various proteolytic enzymes.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and tools for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for clients.
• Academic Research: Used in university and institutional labs for methodological development and the exploration of new chemical entities.

Basic Information

Product Name	3-tert-Butoxycarbonylamino-3-Methyl-Butyric Acid
CAS No.	129765-95-3
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	Boc-Amb-OH; Boc-3-amino-3-methylbutyric acid; N-Boc-3-amino-3-methylbutanoic acid; 3-[(tert-Butoxycarbonyl)amino]-3-methylbutanoic acid; 3-Methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; N-(tert-Butoxycarbonyl)-3-amino-3-methylbutyric acid; 3-(Boc-amino)-3-methylbutyric acid
EINECS	Contact for details

Quality Control

Our 3-tert-Butoxycarbonylamino-3-Methyl-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.