Description

5'(R)-C-Methyl-5-Methyluridine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is essential for research institutions and pharmaceutical companies focused on developing next-generation nucleotide analogs and RNA-targeting therapies. The precise stereochemistry and modification pattern make it a valuable tool for probing biological mechanisms and creating potent, selective active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel antiviral and anticancer nucleotide analog prodrugs.
• Antiviral Research: Used in the development of therapeutics targeting RNA viruses, where modified nucleosides are incorporated to inhibit viral replication.
• Oncology Drug Discovery: Serves as a precursor in the creation of chemotherapeutic agents that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Proteomics & Molecular Biology: Utilized in the synthesis of modified oligonucleotides for diagnostic assays, probes, and RNA-based therapeutic platforms.
• Medicinal Chemistry: Provides a scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and metabolic stability.

Basic Information

Product Name	5'(R)-C-Methyl-5-Methyluridine
CAS No.	129745-35-3
Molecular Formula	C11H16N2O6
Molecular Weight	272.25 g/mol
Synonyms	5'-C-Methyl-5-methyluridine (R-isomer); (2R,3R,4R,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methyltetrahydrofuran-3-ol; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-2'-C-methyluridine; Modified Nucleoside; Uridine, 5'-C-methyl-5-methyl-, (R)-
EINECS	Contact for details

Quality Control

Our 5'(R)-C-Methyl-5-Methyluridine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, impurities, and physical characteristics. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.