Description

3-Hydroxy Quinidine is a significant hydroxylated derivative of the classical antiarrhythmic agent quinidine. This compound matters as a key intermediate and reference standard in pharmaceutical research and development, particularly for metabolic studies and the synthesis of novel bioactive molecules. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery, analytical method development, and impurity profiling.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced quinidine analogs and potential new therapeutic agents.
• Metabolite Reference Standard: Used as an analytical standard in LC-MS, HPLC, and other chromatographic methods to identify and quantify 3-hydroxyquinidine, a major metabolite of quinidine, in pharmacokinetic and bioequivalence studies.
• Impurity Standard: Essential for quality control in quinidine API manufacturing to monitor and control process-related impurities.
• Biochemical Research: Tool compound for investigating cytochrome P450 metabolism, drug-drug interactions, and the structure-activity relationships (SAR) of cinchona alkaloids.
• Analytical Method Development: Serves as a certified reference material (CRM) for calibrating instruments and validating analytical procedures in regulatory submissions.

Basic Information

Product Name	3-Hydroxy Quinidine
CAS No.	129702-12-1
Molecular Formula	C20H26N2O3
Molecular Weight	342.43 g/mol
Synonyms	3-Hydroxyquinidine; (9S)-6'-Methoxycinchonan-3,9-diol; Quinidine, 3-hydroxy-; 3-Hydroxy-6'-methoxycinchonan-9-ol; 3α-Hydroxyquinidine; Quinidine 3-ol; 3-Quinidinol
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Quinidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.