Description

(+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane is a high-value, chiral bisphosphine ligand essential for creating highly selective asymmetric catalysts. Its core value lies in enabling the synthesis of enantiomerically pure compounds, which is critical for developing advanced pharmaceuticals and fine chemicals. This ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the production of enantiomerically enriched pharmaceutical intermediates.
• Catalyst component in the synthesis of fine chemicals and agrochemicals requiring high stereoselectivity.
• Used in academic and industrial research for developing novel transition metal catalysts for C-C and C-X bond formation.
• Critical for process chemistry in scaling up the manufacture of Active Pharmaceutical Ingredients (APIs) with specific chiral centers.
• Employed in the synthesis of flavors, fragrances, and other high-value chiral compounds.

Basic Information

Product Name	(+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane
CAS No.	129648-07-3
Molecular Formula	C14H28P2
Molecular Weight	258.33 g/mol
Synonyms	(R,R)-Me-DuPhos; (2R,2'R,5R,5'R)-1,1',2,2',3,3',4,4',5,5'-Decahydro-1,1'-bi-1,3-benzodiphosphole; (R,R)-1,2-Bis(2,5-dimethylphospholano)ethane; DuPhos ligand (R,R)-isomer; (R,R)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)ethane; (R,R)-Me-BPE; (2R,5R)-2,5-Dimethylphospholane ethane dimer
EINECS	Contact for details

Quality Control

Our (+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We support cGMP and ISO standards for materials intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (ee)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.