Description

n-Boc-3,5-Difluoroaniline is a protected aniline derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and critical building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fluorinated fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where the difluoroaniline moiety can enhance biological activity and metabolic stability.
• Peptide Mimetics & PROTACs: Employed in the synthesis of non-peptidic scaffolds and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine functionality.
• Material Science: Serves as a monomer or precursor for the development of advanced polymers and functional materials with specific electronic or surface properties.
• Ligand & Catalyst Development: Useful for creating novel ligands for catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a starting material for fluorescent tags or other molecular probes used in biochemical assays.

Basic Information

Item	Details
Product Name	n-Boc-3,5-Difluoroaniline
CAS No.	129589-62-4
Molecular Formula	C11H13F2NO2
Molecular Weight	229.22 g/mol
Synonyms	tert-Butyl (3,5-difluorophenyl)carbamate; N-(tert-Butoxycarbonyl)-3,5-difluoroaniline; 3,5-Difluoroaniline, N-BOC-protected; 1,3-Difluoro-5-[(2-methylpropan-2-yl)oxycarbonylamino]benzene; Boc-3,5-Difluoroaniline; N-Boc-3,5-difluoroaniline; BOC-3,5-F2-Ph-NH2; tert-Butoxycarbonyl-3,5-difluoroaniline
EINECS	Contact for details

Quality Control

Our n-Boc-3,5-Difluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.