Description

2,4,5-Trifluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its unique trifluoromethyl ketone ester structure makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals where the introduction of fluorine atoms is critical for modulating biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronics: Employed in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of specialty polymers with unique surface and thermal properties.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination reactions in academic and industrial R&D labs.

Basic Information

Product Name	2,4,5-Trifluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester
CAS No.	129527-43-1
Molecular Formula	C10H7F3O3
Molecular Weight	232.16 g/mol
Synonyms	Methyl 3-(2,4,5-trifluorophenyl)-3-oxopropanoate; 3-Oxo-3-(2,4,5-trifluorophenyl)propanoic acid methyl ester; 2,4,5-Trifluorobenzoylacetic acid methyl ester; Methyl 2,4,5-trifluorobenzoylacetate; 129527-43-1; Trifluoromethyl ketone ester intermediate; β-Keto ester derivative
EINECS	Contact for details

Quality Control

Every batch of 2,4,5-Trifluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.