Description

Parathyroid Hormone (14-34) Amide, Tyr(34)- CAS NO 129476-27-3 is a synthetic peptide fragment of the human parathyroid hormone, specifically the active C-terminal region. This compound is a critical research tool for studying calcium and phosphate metabolism, bone biology, and the mechanisms of parathyroid hormone action. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic disorders and osteoporosis research.

Application

• Biomedical Research: Fundamental studies on PTH receptor (PTH1R) binding, activation, and downstream signaling pathways.
• Drug Discovery & Development: Serving as a reference standard, competitor, or lead compound in the development of novel anabolic or catabolic agents for bone diseases.
• In Vitro Assays: Used in cell-based assays (e.g., cAMP stimulation in osteoblast-like cells) to screen for PTH agonists or antagonists.
• Structure-Activity Relationship (SAR) Studies: Investigating the role of specific amino acid residues in PTH peptide function and stability.
• Metabolic Disorder Research: Exploring the role of PTH fragments in calcium homeostasis, renal function, and their potential link to other metabolic conditions.

Basic Information

Product Name	Parathyroid Hormone (14-34) Amide, Tyr(34)-
CAS No.	129476-27-3
Molecular Formula	C106H165N33O30
Molecular Weight	~2350.65 g/mol
Synonyms	PTH (14-34) Amide, Tyr34; hPTH (14-34) Amide; Parathyroid Hormone Fragment 14-34 Amide; [Tyr34]hPTH(14-34) Amide; PTHrP (14-34) Amide (related analog); PTH-Related Protein Fragment; Calcium Metabolism Research Peptide; CAS 129476-27-3
EINECS	Contact for details

Quality Control

Every batch of our Parathyroid Hormone (14-34) Amide, Tyr(34)- is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to support research reproducibility, including purity verification by multiple orthogonal methods. Certificates of Analysis (COA) detailing purity, identity, and peptide content are available for each lot and supplied upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.