Description

3-(2-Hydroxy-3-(2-Nitro-1H-Imidazol-1-Yl)Propyl)-2-Oxazolidinone is a specialized nitroimidazole derivative with a unique oxazolidinone moiety, serving as a critical pharmaceutical intermediate. Its molecular structure is engineered to act as a key building block in the synthesis of novel therapeutic agents, particularly those targeting anaerobic bacteria and hypoxic tumor cells. This high-purity compound is essential for research and development laboratories, as well as production facilities, in the pharmaceutical and biotechnology sectors seeking to develop next-generation antimicrobial and anticancer drugs.

Application

• Pharmaceutical Intermediate: Primary use as a key synthon in the research and commercial synthesis of novel nitroimidazole-based antibiotics and chemotherapeutic agents.
• Antimicrobial Drug Development: Serves as a core scaffold for developing compounds active against anaerobic bacteria and protozoal infections.
• Hypoxia-Targeting Therapeutics: Used in the development of prodrugs and radiosensitizers designed to selectively target and eradicate hypoxic cells in solid tumors.
• Biochemical Research: Employed in mechanistic studies to understand the bio-reduction and DNA-binding interactions of nitroheterocyclic compounds.
• Preclinical Candidate Synthesis: A vital starting material for medicinal chemistry programs aiming to optimize pharmacokinetic and toxicity profiles of drug candidates.

Basic Information

Product Name	3-(2-Hydroxy-3-(2-Nitro-1H-Imidazol-1-Yl)Propyl)-2-Oxazolidinone
CAS No.	129449-06-5
Molecular Formula	C9H12N4O5
Molecular Weight	256.22 g/mol
Synonyms	1-(2,3-Dihydroxypropyl)-2-nitroimidazole oxazolidinone derivative; 2-Oxazolidinone, 3-[2-hydroxy-3-(2-nitro-1H-imidazol-1-yl)propyl]-; NSC 684681; AKOS005249065; 1-(2,3-Dihydroxypropyl)-5-nitroimidazole oxazolidinone (related isomer); Nitroimidazole-oxazolidinone hybrid; Hypoxia-targeting intermediate
EINECS	Contact for details

Quality Control

Our 3-(2-Hydroxy-3-(2-Nitro-1H-Imidazol-1-Yl)Propyl)-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.