Description

Fmoc-Phe-Ol is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled elongation of peptide chains with its Fmoc-protected amino group and free hydroxyl terminus. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide hormones, and biochemical probes. Its reliable quality ensures reproducibility and efficiency in complex synthetic workflows.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the Fmoc-strategy, used to incorporate phenylalanine residues into growing peptide chains.
• Pharmaceutical Research: Key intermediate in the research and development of peptide-based drugs, hormones, and diagnostic agents.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: The hydroxyl group allows for further chemical modification, enabling the creation of peptide conjugates for labeling or targeting.
• Academic & Industrial R&D: Employed in biochemical and biophysical studies to investigate protein-protein interactions and enzyme mechanisms.
• Synthesis of Modified Peptides: Facilitates the production of peptides containing non-natural amino acids or specific side-chain modifications.

Basic Information

Product Name	Fmoc-Phe-Ol
CAS No.	129397-83-7
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-Phenylalaninol; N-(9-Fluorenylmethoxycarbonyl)-L-phenylalaninol; (2S)-3-Phenyl-2-[(9H-fluoren-9-ylmethoxy)formamido]propan-1-ol; Fmoc-L-Phenylalaninol; N-α-Fmoc-L-phenylalaninol; Fmoc-Phe-ol; N-Fmoc-L-phenylalaninol; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropan-1-ol
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, optical rotation for chiral integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.