Description

Hiv (Gp120) Fragment (421-438) CAS NO 129318-38-3 is a synthetic peptide fragment corresponding to a specific region of the HIV-1 envelope glycoprotein gp120. This high-purity biochemical is a critical research tool for studying viral entry mechanisms, antigen-antibody interactions, and for the development of diagnostic assays and vaccine candidates. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on virology and immunology.

Application

• Biomedical Research: Used as a key antigen in fundamental studies of HIV-1 structure, function, and host cell receptor binding (e.g., CD4 interaction).
• Immunoassay Development: Serves as a coating antigen or standard in the development and calibration of ELISA and other immunoassays for antibody detection.
• Vaccine Research: Employed in epitope mapping and as an immunogen to evaluate immune responses for potential HIV vaccine candidates.
• Antibody Characterization: Essential for screening, characterizing, and neutralizing monoclonal or polyclonal antibodies targeting the gp120 protein.
• Diagnostic Reagent Production: Integrated into in-vitro diagnostic (IVD) kits for the specific and sensitive detection of HIV-related antibodies.
• Structural Biology Studies: Used in techniques like X-ray crystallography or NMR to elucidate the three-dimensional conformation of this gp120 region.

Basic Information

Product Name	Hiv (Gp120) Fragment (421-438)
CAS No.	129318-38-3
Molecular Formula	C85H134N24O27S
Molecular Weight	1971.2 g/mol
Synonyms	HIV-1 gp120 (421-438) peptide; HIV-1 IIIB gp120 (421-438); gp120 Fragment (421-438); HIV envelope glycoprotein gp120 peptide fragment; HGP-30 related peptide; T1-SP10 MN peptide; V3 loop proximal region peptide; Synthetic HIV-1 gp120 antigen
EINECS	Contact for details

Quality Control

Every batch of Hiv (Gp120) Fragment (421-438) is manufactured and tested under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This peptide is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.