Description

Iberiotoxin is a potent and selective high-conductance calcium-activated potassium (BKCa) channel blocker, originally isolated from the venom of the East Indian red scorpion. This specificity makes it an invaluable research tool for studying ion channel physiology, neuronal excitability, and smooth muscle contractility. It is primarily used by researchers and scientists in the fields of neuroscience, cardiovascular pharmacology, and electrophysiology for target validation and mechanistic studies.

Application

• Neuroscience Research: Used to study the role of BKCa channels in neurotransmitter release, neuronal firing patterns, and synaptic plasticity.
• Cardiovascular Research: Employed to investigate vascular tone regulation, smooth muscle function, and the pathophysiology of hypertension.
• Electrophysiology: A critical tool for patch-clamp experiments to characterize and block BKCa channel currents with high specificity.
• Drug Discovery & Target Validation: Serves as a reference standard in screening assays to identify novel modulators of potassium channels.
• Toxicology Studies: Used to understand the mechanisms of scorpion venom toxins and their physiological effects.
• Cell Signaling Pathways: Applied in research exploring calcium signaling cascades and their impact on cellular excitability.

Basic Information

Product Name	Iberiotoxin
CAS No.	129203-60-7
Molecular Formula	C179H274N52O55S7
Molecular Weight	4237.9 g/mol
Synonyms	Iberiotoxin; IbTX; BgK; Potassium channel toxin α-KTx 1.3; Charybdotoxin homolog; Scorpion toxin BgK; BK channel blocker; Maxi-K channel inhibitor
EINECS	Contact for details

Quality Control

Our Iberiotoxin is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional activity. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Biological Activity (IC50)	1-10 nM (BKCa channel inhibition)
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.