Description

n-[tert-Butyl-Carbonyl]-4-Iodo-L-Phenylalanine Phenylmethyl Ester is a protected, iodinated derivative of the essential amino acid L-phenylalanine. This compound is a crucial chiral building block and advanced pharmaceutical intermediate in modern organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, particularly in peptide-based drug discovery and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce iodinated phenylalanine residues, enabling further functionalization via cross-coupling reactions.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of targeted molecular libraries.
• Radiolabeling Precursor: The iodine atom provides a potential site for radioiodination (e.g., with I-125 or I-131) for diagnostic imaging or therapeutic radiopharmaceuticals.
• Bioconjugation: Acts as a linker or modified amino acid for the site-specific conjugation of drugs, dyes, or other molecules to peptides and proteins.

Basic Information

Item	Details
Product Name	n-[tert-Butyl-Carbonyl]-4-Iodo-L-Phenylalanine Phenylmethyl Ester
CAS No.	129150-58-9
Molecular Formula	C21H22INO4
Molecular Weight	479.31 g/mol
Synonyms	Boc-4-Iodo-L-Phenylalanine benzyl ester; Boc-Phe(4-I)-OBzl; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-iodophenyl)propanoic acid benzyl ester; N-Boc-4-iodo-L-phenylalanine benzyl ester; Boc-L-Phe(4-I)-OBn; tert-Butyl (S)-(1-(benzyloxy)-1-oxo-3-(4-iodophenyl)propan-2-yl)carbamate; 4-Iodo-N-Boc-L-phenylalanine benzyl ester
EINECS	Contact for details

Quality Control

Our n-[tert-Butyl-Carbonyl]-4-Iodo-L-Phenylalanine Phenylmethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification (NMR, IR). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.