Description

(D-Phe12,Nle21,38)-Crf (12-41) (Human, Rat) CAS NO 129133-27-3 is a synthetic peptide analog of the corticotropin-releasing factor (CRF) receptor antagonist, Astressin. This compound is a critical research tool for investigating the hypothalamic-pituitary-adrenal (HPA) axis and stress-related disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on neuroendocrinology, anxiety, depression, and metabolic disease models.

Application

• Neuroscience Research: As a potent CRF receptor antagonist for studying stress response pathways and central nervous system function.
• Pharmacological Studies: For in vitro and in vivo characterization of CRF receptor binding affinity, selectivity, and antagonistic activity.
• Preclinical Drug Development: Serving as a reference standard or tool compound in the discovery of novel therapeutics for anxiety, depression, and addiction.
• Endocrine Research: Investigating the regulation of the HPA axis and its role in conditions like Cushing's syndrome or adrenal insufficiency.
• Biomarker Assay Development: Used in the development and validation of immunoassays or other analytical methods targeting CRF pathways.
• Academic & Institutional Research: Fundamental research in physiology, psychiatry, and behavioral science to elucidate stress mechanisms.

Basic Information

Product Name	(D-Phe12,Nle21,38)-Crf (12-41) (Human, Rat)
CAS No.	129133-27-3
Molecular Formula	C184H301N57O51
Molecular Weight	~4167.8 g/mol
Synonyms	Astressin; (D-Phe12,Nle21,38)-Corticotropin-Releasing Factor (12-41); (D-Phe12,Nle21,38)-h/rCRF(12-41); CRF (12-41) Antagonist; Cyclo(30-33)[Ac-Pro30,D-Phe12,Nle21,38,Glu30,Lys33]h/rCRF(12-41); h/rCRF(12-41) Antagonist; Corticotropin-Releasing Hormone Antagonist (12-41)
EINECS	Contact for details

Quality Control

Every batch of (D-Phe12,Nle21,38)-Crf (12-41) is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. Our quality commitment includes adherence to GMP principles for research-grade peptides. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), molecular weight (MS), and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥95% (Area Percent)
Peptide Content	≥70% (by weight)
Water Content (KF)	≤8.0%
Acetate Content (HPLC)	≤15.0%
Biological Activity	Confirmed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.