Description

α-Cgrp (8-37) (Rat) is a synthetic peptide fragment corresponding to residues 8-37 of the rat calcitonin gene-related peptide (CGRP) alpha isoform. This compound serves as a potent and selective antagonist of the CGRP receptor, making it a critical tool for neurological and cardiovascular research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) investigating migraine pathways, neurogenic inflammation, and vascular biology.

Application

• Neuroscience Research: Used as a selective CGRP receptor antagonist to study the role of CGRP in migraine pathophysiology, pain transmission, and neurogenic inflammation.
• Cardiovascular Studies: Employed in preclinical models to investigate CGRP-mediated vasodilation, blood pressure regulation, and vascular tone.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool for screening and validating novel CGRP-targeted therapeutics for migraine and other disorders.
• Academic & Institutional Research: A key reagent for in vitro (cell-based assays) and in vivo (animal model) studies exploring CGRP signaling pathways.
• Biochemical Assay Development: Used to establish competitive binding assays (e.g., receptor binding, ELISA) to quantify CGRP activity or antagonist potency.

Basic Information

Product Name	α-Cgrp (8-37) (Rat)
CAS No.	129121-73-9
Molecular Formula	C142H244N46O41S
Molecular Weight	3203.8 g/mol
Synonyms	α-CGRP (8-37), rat; Calcitonin Gene-Related Peptide (8-37), rat alpha; CGRP-(8-37), rat; rCGRPα-(8-37); α-Calcitonin Gene-Related Peptide Fragment 8-37 (Rat); CGRP receptor antagonist (rat); Tyr-Ser-Phe-Gly-Val-Val-Thr-Asp-Val-Phe-His-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 (rat sequence)
EINECS	Contact for details

Quality Control

Our α-Cgrp (8-37) (Rat) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and MS for identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting purity, peptide content, and solvent residues. We support research requiring compliance with cGMP guidelines for non-clinical materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.