Description

Egfrviii Peptide (Pepviii) CAS NO 129112-17-0 is a synthetic peptide sequence corresponding to a specific mutation in the Epidermal Growth Factor Receptor (EGFR), a key target in oncology research. This compound is of critical importance for the development and validation of targeted cancer therapies and diagnostic tools. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on glioblastoma, immunotherapy, and novel antibody-drug conjugate (ADC) development.

Application

• Immunotherapy Research: Used as a critical antigen for the development and screening of CAR-T cells, bispecific antibodies, and other immunotherapies targeting the EGFRvIII mutation.
• Diagnostic Assay Development: Serves as a key component in ELISA, Western Blot, and other immunoassays for detecting EGFRvIII expression in tumor samples.
• Vaccine Development: Employed as an immunogen in pre-clinical studies for cancer vaccine candidates aimed at eliciting a specific immune response against EGFRvIII-positive tumors.
• Antibody Production & Characterization: Essential for the generation, purification, and affinity testing of monoclonal antibodies specific to the EGFRvIII epitope.
• Cell Signaling Studies: Utilized in biochemical assays to study the aberrant signaling pathways driven by the constitutively active EGFRvIII mutant receptor.
• Quality Control Reference Standard: Acts as a reference material for the quality control of biologics and diagnostic kits targeting the EGFRvIII mutation.

Basic Information

Product Name	Egfrviii Peptide (Pepviii)
CAS No.	129112-17-0
Molecular Formula	Typically C~40H~70N~12O~13 (Sequence-dependent; contact for exact formula)
Molecular Weight	~ 1000 - 1500 g/mol (Sequence-dependent)
Synonyms	EGFRvIII Peptide; PEPVIII; EGFR Type III Mutant Peptide; Epidermal Growth Factor Receptor Variant III Peptide; vIII Peptide; DeltaEGFR Peptide; LEEKKGNYVVTDHC (example sequence); De2-7 EGFR Peptide
EINECS	Contact for details

Quality Control

Our Egfrviii Peptide is manufactured under strict quality systems suitable for research and pre-clinical applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, MS, and amino acid analysis are provided with every shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Molecular Weight (MS)	Conforms to theoretical value (± 2 Da)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.