Description

Curosurf CAS NO 129069-19-8 is a natural porcine lung surfactant, a complex mixture of phospholipids and hydrophobic surfactant-associated proteins. This product is critical for the treatment of Respiratory Distress Syndrome (RDS) in premature infants, where it acts to reduce alveolar surface tension and improve lung compliance. It is an essential pharmaceutical active ingredient for manufacturers of life-saving neonatal respiratory medications, requiring the highest standards of purity, consistency, and biological activity.

Application

• Primary active pharmaceutical ingredient (API) in surfactant replacement therapy for neonatal medicine.
• Treatment and prophylaxis of Respiratory Distress Syndrome (RDS) in premature infants.
• Research and development of advanced pulmonary surfactant formulations.
• Manufacturing of sterile, injectable pharmaceutical preparations for critical care.
• Biochemical research into lung physiology and surfactant metabolism.
• Reference standard for quality control in pharmaceutical production.

Basic Information

Item	Details
Product Name	Curosurf
CAS No.	129069-19-8
Molecular Formula	Complex biological extract; primarily phospholipids (e.g., DPPC) and proteins (SP-B, SP-C)
Molecular Weight	N/A (Heterogeneous mixture)
Synonyms	Poractant Alfa; Porcine Lung Surfactant; Natural Lung Surfactant; Pulmonary Surfactant; Calfactant (bovine analogue); Beractant; Survanta; Alveofact; Surfactant TA; Phospholipid Fraction from Porcine Lung; KL-4 Surfactant (synthetic analogue); Lucinactant
EINECS	Contact for details

Quality Control

Our Curosurf is manufactured and controlled under strict pharmaceutical standards. Each batch undergoes comprehensive testing to ensure identity, purity, potency, and safety, meeting the specifications for use as an active pharmaceutical ingredient. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with relevant pharmacopeial and internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store refrigerated at 2°C to 8°C. Do not freeze. Handle under aseptic conditions appropriate for a sterile pharmaceutical product.

Specification

Item	Specification
Description	Sterile suspension, white to off-white
Identification (HPLC/Activity)	Complies
Phospholipid Content	≥ 80 mg/mL
Phosphatidylcholine (as % of total phospholipids)	≥ 70%
Surface Activity (Wilhelmy Balance)	≤ 25 mN/m (minimum surface tension)
pH	5.0 - 6.0
Sterility	Sterile (complying with Ph. Eur. 2.6.1 / USP <71>)
Bacterial Endotoxins	< 10 EU/mL
Protein Content	1.0 - 2.0 mg/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.