Description

Boc-Asp-Ofm is a protected aspartic acid derivative, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptide sequences. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides and peptidomimetics, where high purity and reliable performance are non-negotiable.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of aspartic acid, preventing unwanted side reactions.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Serves as a linker or modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic & Institutional Research: Fundamental reagent for studying peptide structure, function, and synthesis methodologies.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-Asp-Ofm
CAS No.	129046-87-3
Molecular Formula	C19H25NO7
Molecular Weight	379.41 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-aspartic acid β-9-fluorenylmethyl ester; Boc-L-Aspartic acid 4-9-fluorenylmethyl ester; Boc-Asp(O-Fm)-OH; Boc-L-Asp(O-Fm)-OH; (2S)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; N-Boc-L-aspartic acid 4-fluorenylmethyl ester; Fmoc-Asp(OtBu)-OH (Note: This is a different, common protected form); L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(9H-fluoren-9-ylmethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Asp-Ofm is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.