Description

Org 5222 Glucuronide is a high-purity reference standard and synthetic intermediate of significant importance in pharmaceutical research and development. This compound is critical for analytical method development, metabolite identification, and pharmacokinetic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and bioanalytical chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification and qualification of drug metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolite Synthesis & Research: Serves as a key intermediate or final product in the synthesis of glucuronidated metabolites for pharmacological and toxicological profiling.
• Enzyme Activity Studies: Employed in assays to study the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Bioanalytical Method Development: Essential for developing and validating robust analytical methods for drug and metabolite detection in compliance with GLP guidelines.
• Impurity Standard: Used to identify and control potential glucuronide-related impurities in active pharmaceutical ingredient (API) batches.
• Preclinical & Clinical Research: Supports drug metabolism and pharmacokinetics (DMPK) studies during preclinical development and clinical trials.

Basic Information

Product Name	Org 5222 Glucuronide
CAS No.	128923-28-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ORG 5222 Glucuronide; Org5222 Glucuronide; 128923-28-4; (Compound related to Org 5222); Potential metabolite of Org 5222; Glucuronide conjugate of Org 5222
EINECS	Contact for details

Quality Control

Our Org 5222 Glucuronide is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods (e.g., HPLC, NMR) is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.