Description

Fmoc-12-Aminododecanoic Acid CAS NO 128917-74-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its primary value lies in its role as a key building block for introducing a long, hydrophobic spacer arm with a terminal primary amine, enabling the controlled synthesis of complex peptides and peptide conjugates. This compound is critically needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic probes, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the automated or manual synthesis of custom peptide sequences.
• Linker and Spacer Chemistry: Incorporation of a 12-carbon aliphatic chain to create spacers between a peptide and a solid support, fluorophore, or other functional moiety.
• Peptide-Polymer Conjugate Development: Facilitating the site-specific attachment of peptides to polymers for drug delivery systems and biomaterial engineering.
• Antibody-Drug Conjugate (ADC) Research: Used in the synthesis of peptide linkers for connecting cytotoxic payloads to monoclonal antibodies.
• Surface Functionalization: Creating amine-terminated surfaces on biosensors, chips, or nanoparticles via peptide-based coatings.
• Combinatorial Chemistry Libraries: A versatile intermediate for generating diverse libraries of compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-12-Aminododecanoic Acid
CAS No.	128917-74-8
Molecular Formula	C27H35NO4
Molecular Weight	437.57 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-12-aminododecanoic Acid; Fmoc-12-ADA-OH; 12-[(9-Fluorenylmethyloxycarbonyl)amino]dodecanoic Acid; N-Fmoc-12-aminolauric Acid; Fmoc-NH-(CH2)11-COOH; N-α-Fmoc-1,12-diaminododecanoic Acid (protected form); Fmoc-Dodecanedioic acid monoamide; (12-Aminododecanoic acid), N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-12-Aminododecanoic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.