Description

(S)-4,4,4-Trifluoro-3-Hydroxybutyric Acid CAS NO 128899-79-6 is a high-value chiral building block characterized by a trifluoromethyl group and a hydroxyl functionality on a short carbon chain. This compound is essential for introducing the metabolically stable trifluoromethyl group into target molecules, significantly enhancing their lipophilicity and biological activity. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drugs, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the trifluoromethyl group improves efficacy and environmental stability.
• Fluorinated Building Block: Serves as a versatile precursor for synthesizing a wide range of organofluorine compounds in medicinal and materials chemistry.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and catalysts for asymmetric synthesis.
• Biochemical Research: Used as a probe or substrate in enzymatic studies and metabolic pathway investigations.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	(S)-4,4,4-Trifluoro-3-Hydroxybutyric Acid
CAS No.	128899-79-6
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	(S)-3-Hydroxy-4,4,4-trifluorobutanoic Acid; (S)-4,4,4-Trifluoro-3-hydroxybutanoic Acid; (3S)-4,4,4-Trifluoro-3-hydroxybutyric Acid; (S)-TFHB; (S)-Trifluorohydroxybutyric Acid; (S)-3-Hydroxy-4,4,4-trifluorobutyric Acid; (S)-3-Hydroxyperfluorobutyric Acid
EINECS	Contact for details

Quality Control

Our (S)-4,4,4-Trifluoro-3-Hydroxybutyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.