Description

n-(3-Fluoropropyl)-n-Norbuprenorphine is a high-purity synthetic chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel opioid receptor ligands and other specialized pharmacologically active molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on neuropharmacology and analgesic drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel buprenorphine analogs and opioid receptor modulators.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies targeting the opioid receptor family.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in forensic and clinical toxicology.
• Biochemical Research: Employed in vitro studies to investigate ligand-receptor interactions and signal transduction pathways.
• Process Chemistry: Utilized in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	n-(3-Fluoropropyl)-n-Norbuprenorphine
CAS No.	128837-83-2
Molecular Formula	C29H38FNO4
Molecular Weight	483.62 g/mol
Synonyms	21-Cyclopropyl-7-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-ethano-6,7,8,14-tetrahydro-4-[(3-fluoropropyl)amino]nororipavine; 4-[(3-Fluoropropyl)amino]-6,14-ethenomorphinan-7-methanol, 21-cyclopropyl-α-(1,1-dimethylethyl)-α-ethenyl-; N-(3-Fluoropropyl)norbuprenorphine; Nor-Buprenorphine N-(3-fluoropropyl) derivative; Buprenorphine Impurity; BPN N-Fluoropropyl analog
EINECS	Contact for details

Quality Control

Our n-(3-Fluoropropyl)-n-Norbuprenorphine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.