Description

4-Trifluoromethylphenylboronic Acid CAS NO 128796-39-4 is a high-value organoboron compound featuring a phenyl ring substituted with both a boronic acid group and a trifluoromethyl group. This unique structure makes it an essential building block in modern synthetic chemistry, particularly for the Suzuki-Miyaura cross-coupling reaction, a cornerstone method for forming carbon-carbon bonds. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups known to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the CF3 group can improve efficacy and environmental profile.
• Material Science: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura coupling with aryl halides to create biaryl structures, a fundamental transformation in medicinal and process chemistry.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries.
• Ligand Synthesis: Can be used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Trifluoromethylphenylboronic Acid
CAS No.	128796-39-4
Molecular Formula	C7H6BF3O2
Molecular Weight	189.93 g/mol
Synonyms	(4-(Trifluoromethyl)phenyl)boronic acid; p-(Trifluoromethyl)phenylboronic acid; 4-(Trifluoromethyl)benzeneboronic acid; B-[4-(Trifluoromethyl)phenyl]boronic acid; 4-CF3-Phenylboronic Acid; 4-Trifluoromethylbenzeneboronic Acid; 4-Trifluoromethyl-Benzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.