Description

Ciliary Neurotrophic Factor, Rat is a recombinant protein that acts as a potent neurotrophic cytokine, crucial for the survival and differentiation of various neuronal populations. This high-purity factor is essential for advanced neuroscience research, drug discovery, and cell culture applications where precise biological activity is required. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurobiology, neuroprotection, and regenerative medicine.

Application

• Neuroscience Research: Used as a key reagent in studies investigating neuronal survival, differentiation, and synaptic plasticity.
• Cell Culture & Differentiation: Supports the growth and maintenance of specific neuronal cell types, including motor neurons and sensory neurons, in vitro.
• Drug Discovery Screening: Serves as a positive control or active component in high-throughput assays targeting neurotrophic pathways for therapeutic development.
• Disease Modeling: Applied in cellular models of neurodegenerative diseases (e.g., Amyotrophic Lateral Sclerosis, Parkinson's) to study protective mechanisms.
• Biomanufacturing & Process Development: Used in the development and optimization of production processes for other biological therapeutics.
• Reagent for Assay Development: Essential for standardizing and validating ELISA kits, bioassays, and other diagnostic tools related to neurotrophic activity.

Basic Information

Product Name	Ciliary Neurotrophic Factor, Rat
CAS No.	128558-25-8
Molecular Formula	Contact for details
Molecular Weight	~22-24 kDa (monomer)
Synonyms	Rat CNTF; Recombinant Rat Ciliary Neurotrophic Factor; CNTF, Rat; Axokine (related); Neurotrophic Factor, Ciliary; Gliosis-Inhibiting Factor; HCNTF (Human variant); Recombinant CNTF
EINECS	Contact for details

Quality Control

Our Ciliary Neurotrophic Factor, Rat is produced under stringent conditions to ensure the highest levels of purity and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, HPLC, and endotoxin level analysis, to guarantee consistency and performance. Certificates of Analysis (COA) detailing purity, potency (specific activity in units/mg), and sterility are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. Once reconstituted, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by cell-based proliferation assay (e.g., TF-1 cell line)
Sterility (Membrane Filtration)	Sterile
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.