Description

n-Crotonyl-(4S,5R)-4-Methyl 5-Phenyl-2-Oxazolidinone is a high-purity chiral auxiliary and building block of significant importance in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric excess in the final products. This compound is essential for research and production in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Aldol Reactions: Serves as a highly effective chiral auxiliary for the enantioselective formation of carbon-carbon bonds.
• Pharmaceutical Intermediate: A critical building block in the synthesis of chiral drugs, including protease inhibitors and other bioactive molecules.
• Fine Chemical Synthesis: Used in the production of specialty chemicals requiring precise stereochemical control.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic and medicinal chemistry laboratories.
• Peptidomimetics: Facilitates the synthesis of peptide-like compounds with enhanced stability and biological activity.
• Catalyst Ligand Precursor: Can be utilized in the development of novel chiral ligands for asymmetric catalysis.

Basic Information

Product Name	n-Crotonyl-(4S,5R)-4-Methyl 5-Phenyl-2-Oxazolidinone
CAS No.	128440-43-7
Molecular Formula	C₁₄H₁₅NO₃
Molecular Weight	245.27 g/mol
Synonyms	(4S,5R)-4-Methyl-5-phenyl-3-[(2E)-2-butenoyl]-2-oxazolidinone; (4S,5R)-3-Crotonoyl-4-methyl-5-phenyl-2-oxazolidinone; (4S,5R)-N-Crotonyl-4-methyl-5-phenyloxazolidin-2-one; Evans Auxiliary Derivative; Crotonyl Evans Auxiliary; (S,R)-4-Methyl-5-phenyl-3-(2-butenoyl)-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our n-Crotonyl-(4S,5R)-4-Methyl 5-Phenyl-2-Oxazolidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.