Description

2-Chloro-2,3,3-trifluoro-1-methyl-cyclobutanecarboxylic acid methyl ester is a high-value fluorinated cyclobutane derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a chlorine atom and three fluorine atoms on a cyclobutane ring, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated and chlorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorinated cyclobutane core can enhance biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated polymers or liquid crystals with unique thermal and chemical resistance properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for cycloaddition reactions and the construction of strained, multi-substituted ring systems for various specialty chemical applications.

Basic Information

Product Name	2-Chloro-2,3,3-trifluoro-1-methyl-cyclobutanecarboxylic acid methyl ester
CAS No.	128146-98-5
Molecular Formula	C8H9ClF3O2
Molecular Weight	220.60 g/mol
Synonyms	Methyl 2-chloro-2,3,3-trifluoro-1-methylcyclobutanecarboxylate; 1-Methyl-2-chloro-2,3,3-trifluorocyclobutanecarboxylic Acid Methyl Ester; 2-Chloro-2,3,3-trifluoro-1-methylcyclobutanecarboxylic Acid Methyl Ester; Methyl 1-methyl-2-chloro-2,3,3-trifluorocyclobutanecarboxylate; Cyclobutanecarboxylic acid, 2-chloro-2,3,3-trifluoro-1-methyl-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-2,3,3-trifluoro-1-methyl-cyclobutanecarboxylic acid methyl ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to meet the stringent requirements of our pharmaceutical and agrochemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and organic solvents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.