Description

4-(Difluoromethoxy)Iodobenzene is a versatile and high-value organoiodine building block characterized by its difluoromethoxy and iodo substituents on the benzene ring. This compound is essential for introducing the difluoromethoxy-phenyl moiety into complex molecules, a key step in the development of advanced materials and active pharmaceutical ingredients. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for use in cross-coupling reactions and as a precursor in fluorinated compound synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring the difluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental persistence.
• Cross-Coupling Reactions: Serves as a superior aryl iodide partner in palladium-catalyzed reactions such as Suzuki, Sonogashira, and Heck couplings for constructing biaryl and complex aromatic systems.
• Liquid Crystal & OLED Material Research: Employed as a precursor in the development of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination methodologies and the properties of fluorinated aromatic ethers.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for radiolabeling with fluorine-18 for diagnostic imaging agents.

Basic Information

Item	Detail
Product Name	4-(Difluoromethoxy)Iodobenzene
CAS No.	128140-82-9
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	1-Iodo-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)iodobenzene; 4-Iodophenyl difluoromethyl ether; Difluoromethoxybenzene, 4-iodo-; Benzene, 1-iodo-4-(difluoromethoxy)-; Iodobenzene, 4-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.