Description

1,2-Distearoyl-Sn-Glycero-3-Phospho-n-(4-Azido-3-Iodo-2-Hydroxybenzoyl)Ethanolamine is a specialized, functionalized phospholipid derivative designed for advanced bioconjugation and labeling applications. Its core value lies in the unique combination of a photoactivatable aryl azide group and a phospholipid backbone, enabling efficient, covalent cross-linking to biomolecules upon UV irradiation. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and advanced material science who require precise tools for membrane protein studies, liposome surface modification, and the creation of targeted drug delivery systems.

Application

• Membrane Protein Labeling and Cross-linking: Used to covalently tag and study membrane-associated proteins in lipid bilayers for structural and functional analysis.
• Liposome and Nanoparticle Functionalization: Enables the surface modification of lipid-based carriers with targeting ligands, antibodies, or other biomolecules for targeted drug delivery.
• Bioconjugation Reagent: Serves as a key intermediate for creating photo-affinity probes to investigate protein-lipid or protein-protein interactions.
• Proteomics Research: Facilitates the identification and isolation of interacting partners in complex biological membranes.
• Biomaterial Surface Engineering: Applied to create bioactive coatings on implants or diagnostic devices by incorporating the phospholipid into supported lipid membranes.
• Diagnostic Assay Development: Used in the development of sensitive immunoassays or biosensors that require stable immobilization of capture molecules on a lipid interface.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycero-3-Phospho-n-(4-Azido-3-Iodo-2-Hydroxybenzoyl)Ethanolamine
CAS No.	128129-55-5
Molecular Formula	C46H80IN3O11P
Molecular Weight	1008.01 g/mol
Synonyms	DSPE-PEG-N3 (Iodoaryl Azide); 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[4-azido-3-iodo-2-hydroxybenzoyl]; Photoactivatable Phospholipid; Aryl Azide DSPE; N-(4-Azido-3-iodo-2-hydroxybenzoyl)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine; Iodoaryl Azide Phosphatidylethanolamine; Photo-crosslinking Lipid; N-Hydroxysuccinimide Ester of DSPE-PEG-Azide (precursor); DSPE-PEGn-N3 (Iodo variant)
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical is governed by strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment to consistent quality and supply reliability supports critical life science and pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, DMSO, DMF; insoluble in water
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.