Description

Iomazenil is a high-purity benzodiazepine receptor ligand, specifically a partial inverse agonist, with the CAS registry number 127985-21-1. This compound is of significant value in neuroscience research and pharmaceutical development due to its selective binding to central benzodiazepine receptors. It is primarily required by research institutions, pharmaceutical R&D departments, and diagnostic imaging centers for applications in neuropharmacology and positron emission tomography (PET) studies.

Application

• Neuroscience Research: Used as a selective radioligand in receptor binding assays to study the GABAA receptor complex and its modulation.
• PET Imaging Agent: Serves as a precursor for the synthesis of radiolabeled (e.g., [123I]Iomazenil) tracers for non-invasive imaging of central benzodiazepine receptor density and distribution in the brain.
• Pharmacological Studies: Employed in vitro and in vivo to investigate the effects of benzodiazepine site ligands, aiding in the understanding of anxiety, epilepsy, and sleep disorders.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Drug Discovery: Utilized in high-throughput screening (HTS) campaigns to identify novel therapeutics targeting the benzodiazepine binding site.
• Clinical Research: Applied in studies exploring receptor occupancy and the pathophysiology of neurological and psychiatric conditions.

Basic Information

Product Name	Iomazenil
CAS No.	127985-21-1
Molecular Formula	C22H21IN4O3
Molecular Weight	516.33 g/mol
Synonyms	Ro 16-0154; Iomazenil (Ro 16-0154); (S)-Iomazenil; 3-Iomazenil; Ethyl 7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 7-iodo-5,6-dihydro-5-methyl-6-oxo-, ethyl ester, (S)-; Ro-16-0154; Ethyl (S)-7-iodo-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Iomazenil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent analysis are provided with every shipment. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.