Description

Kistrin CAS NO 127829-86-1 is a potent and highly specific disintegrin, a class of peptides derived from snake venom that selectively inhibits platelet aggregation. This compound is a critical research tool for studying integrin-mediated cell adhesion and signaling pathways, particularly those involving the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor. It is essential for researchers and developers in the fields of cardiovascular pharmacology, thrombosis research, and cancer metastasis studies, providing a key to unlocking mechanisms of cell-cell and cell-matrix interactions.

Application

• Biomedical Research: As a selective antagonist of the platelet fibrinogen receptor (GPIIb/IIIa), it is used to study mechanisms of platelet aggregation, thrombosis, and hemostasis in vitro.
• Cardiovascular Drug Discovery: Serves as a reference standard and pharmacological tool in the development and screening of novel antiplatelet and antithrombotic agents.
• Cancer Research: Utilized to investigate the role of integrins in tumor cell adhesion, angiogenesis, and metastasis, given its ability to block specific integrin receptors.
• Cell Biology Studies: Applied in assays to understand integrin-mediated cell signaling, cytoskeletal reorganization, and cell migration.
• Biochemical Assay Development: Used as a critical component in developing high-throughput screening (HTS) assays for integrin function and inhibitor discovery.
• Standard Reference Material: Provides a high-purity standard for quality control in related biopharmaceutical production and academic research.

Basic Information

Product Name	Kistrin
CAS No.	127829-86-1
Molecular Formula	C254H383N71O75S6
Molecular Weight	~5750 g/mol (monoisotopic)
Synonyms	Kistrin (Echistatin); Platelet Aggregation Inhibitor (Echis carinatus); GPIIb-IIIa Antagonist; Echistatin α; Integrin αIIbβ3 Inhibitor; Disintegrin Kistrin; EC 3.4.24. (Echistatin); SV-1 (Snake Venom Peptide 1)
EINECS	Contact for details

Quality Control

Our Kistrin is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and sterility (where applicable). We adhere to GMP-like guidelines for peptide synthesis and purification to guarantee batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Potency)	≥ 98% (by functional assay)
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.