Description

(1R,2R)-Bis[tert-Butyl(Phenyl)Phosphino]Ethane is a high-value, chiral bidentate phosphine ligand widely used in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in hydrogenation, cross-coupling, and hydroformylation reactions.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Heck).
• Use in asymmetric hydroformylation to produce chiral aldehydes.
• Key reagent for the synthesis of other complex chiral phosphine ligands and catalysts.
• Research and development of novel catalytic processes in academic and industrial laboratories.
• Production of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Manufacture of specialty chemicals and flavors & fragrances where stereochemistry is crucial.

Basic Information

Product Name	(1R,2R)-Bis[tert-Butyl(Phenyl)Phosphino]Ethane
CAS No.	127759-67-5
Molecular Formula	C30H40P2
Molecular Weight	462.59 g/mol
Synonyms	(R,R)-DIPAMP; (1R,2R)-(-)-1,2-Bis[(2-methoxyphenyl)(phenylphosphino)]ethane (common mis-assignment); (R,R)-Bis(tert-butylphenylphosphino)ethane; (R,R)-t-Bu-BIPHEP (related structure); (R,R)-DTBPE; (1R,2R)-(-)-1,2-Bis(tert-butylphenylphosphino)ethane; (R,R)-Bis(tert-butyl(phenyl)phosphino)ethane; ChiraPhos DTBP
EINECS	Contact for details

Quality Control

Our production of (1R,2R)-Bis[tert-Butyl(Phenyl)Phosphino]Ethane adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, 31P NMR, and 1H NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere). The storage area should be cool, dry, and well-ventilated. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (31P NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.