Description

Regramostim is a recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) analog, a critical cytokine for immune system regulation. Its primary value lies in stimulating the production, differentiation, and function of white blood cells, making it essential for therapeutic applications. This product is vital for pharmaceutical manufacturers and research institutions developing treatments for neutropenia, supporting bone marrow recovery, and advancing immunology research.

Application

• Pharmaceutical Active Ingredient: Core component in injectable formulations for the treatment of chemotherapy-induced neutropenia.
• Bone Marrow Transplant Support: Used to accelerate white blood cell recovery following bone marrow or stem cell transplantation.
• Research & Development: Critical reagent in immunological studies, hematopoiesis research, and preclinical drug development.
• Biopharmaceutical Manufacturing: Serves as a reference standard or an intermediate in the production of biosimilar GM-CSF products.
• Wound Healing Applications: Investigated for its potential role in enhancing tissue repair and combating infections in non-healing wounds.
• Oncology Adjuvant Therapy: Explored as an adjuvant to enhance the efficacy of cancer vaccines and certain immunotherapies.

Basic Information

Product Name	Regramostim
CAS No.	127757-91-9
Molecular Formula	C639H1006N168O198S8
Molecular Weight	Approx. 14,500 Da
Synonyms	Recombinant Human GM-CSF; GM-CSF; Sargramostim; Molgramostim; Granulocyte-Macrophage Colony-Stimulating Factor; CSF2; Colony Stimulating Factor 2; Leukine® (brand name); rhGM-CSF
EINECS	Contact for details

Quality Control

Our Regramostim is manufactured under strict quality management systems. Each batch is subjected to a comprehensive battery of analytical tests including purity assay, biological activity (potency), identity confirmation, and impurity profiling to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under controlled conditions to ensure stability. For long-term storage, consider keeping the product in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Biological Activity (Cell-based assay)	≥ 1.0 x 107 IU/mg
Endotoxin	< 10 EU/mg
Residual Moisture (KF)	≤ 3.0%
Related Proteins (HPLC)	Meets acceptance criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.