Description

Methyl 2-(4-Fluorophenyl)-2-Hydroxyacetate is a versatile fluorinated chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in the combination of the hydroxyacetate ester moiety and the fluorinated aromatic ring, which are key structural motifs for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced fluorinated pesticides and herbicides, where the fluorine atom enhances bioavailability and stability.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or resolving agents due to its stereogenic center.
• Fine Chemical Production: Employed in the manufacture of complex fluorinated aromatics, flavors, and fragrances.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry, including esterification, fluorination, and asymmetric transformation reactions.
• Material Science Precursor: Potential use in synthesizing monomers for specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	Methyl 2-(4-Fluorophenyl)-2-Hydroxyacetate
CAS No.	127709-19-7
Molecular Formula	C9H9FO3
Molecular Weight	184.16 g/mol
Synonyms	Methyl (4-Fluorophenyl)(hydroxy)acetate; 2-Hydroxy-2-(4-fluorophenyl)acetic Acid Methyl Ester; (4-Fluorophenyl)(hydroxy)acetic Acid Methyl Ester; Methyl α-Hydroxy-4-fluorophenylacetate; Methyl DL-4-Fluoromandelate; DL-4-Fluoromandelic Acid Methyl Ester; (±)-Methyl 2-(4-Fluorophenyl)-2-hydroxyacetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Fluorophenyl)-2-Hydroxyacetate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.