Description

4-(Acetoxymethyl)Nitrosamino]-1-(3-Pyridyl)-1-Butanone is a specialized nitrosamine derivative of significant interest in advanced chemical research and development. This compound serves as a critical intermediate and reference standard for analytical and synthetic chemistry applications, particularly in the study of nitrosamine formation and metabolism. It is primarily utilized by research institutions, pharmaceutical development laboratories, and analytical service providers focused on impurity profiling, toxicology studies, and method development.

Application

• Analytical Reference Standard: Used as a certified standard for the accurate quantification and identification of nitrosamine impurities in pharmaceutical products and complex matrices.
• Pharmaceutical Research: Serves as a key intermediate or model compound in studies investigating the formation, stability, and metabolic pathways of nitrosamines for regulatory risk assessment.
• Toxicology & Safety Testing: Employed in *in vitro* and *in vivo* studies to understand the genotoxic and carcinogenic potential of specific nitrosamine structures.
• Method Development & Validation: Critical for developing and validating highly sensitive analytical methods, such as LC-MS/MS and GC-MS, for trace-level nitrosamine detection.
• Chemical Synthesis: Acts as a building block or precursor in the synthesis of more complex molecules for research purposes in medicinal and organic chemistry.
• Quality Control Laboratories: Used to spike samples for recovery studies and to ensure the accuracy and precision of nitrosamine testing protocols in QC/QA environments.

Basic Information

Product Name	4-(Acetoxymethyl)Nitrosamino]-1-(3-Pyridyl)-1-Butanone
CAS No.	127686-49-1
Molecular Formula	C12H15N3O3
Molecular Weight	249.27 g/mol
Synonyms	4-(Acetoxymethyl)-1-(3-pyridyl)-1-nitrosaminobutan-1-one; NNK acetate; 4-(Nitrosoacetoxymethylamino)-1-(3-pyridyl)-1-butanone; 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone; 4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone acetate; N-Nitrosonornicotine ketone acetate derivative; 1-(3-Pyridyl)-1-butanone, 4-[(acetoxymethyl)nitrosamino]-; 4-(Acetoxymethylnitrosamino)-1-(pyridin-3-yl)butan-1-one
EINECS	Contact for details

Quality Control

Our 4-(Acetoxymethyl)Nitrosamino]-1-(3-Pyridyl)-1-Butanone is manufactured and handled under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stability, meeting the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	90.0% - 110.0% of labeled amount
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.