Description

3-Chlorotetrafluoropropanoic Acid Methyl Ester is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound is valued for its unique reactivity profile, offering a versatile trifluoromethyl-containing moiety for the introduction of fluorine into target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where precise fluorination is required to modulate the biological activity, metabolic stability, and lipophilicity of new compounds. The product is supplied to meet the stringent demands of process development and commercial-scale production.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with trifluoromethyl groups to enhance potency and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine atoms improve efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance and durability.
• Specialty Polymer Modifier: Incorporated to create fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and coupling reactions to introduce the 3-chlorotetrafluoropropanoyl moiety into complex organic frameworks.
• Research & Development: A valuable tool for medicinal chemistry and material science research exploring new fluorinated compounds.

Basic Information

Product Name	3-Chlorotetrafluoropropanoic Acid Methyl Ester
CAS No.	127589-63-3
Molecular Formula	C4H3ClF4O2
Molecular Weight	194.51 g/mol
Synonyms	Methyl 3-chlorotetrafluoropropanoate; Methyl 3-chloro-2,2,3,3-tetrafluoropropionate; 3-Chloro-2,2,3,3-tetrafluoropropionic Acid Methyl Ester; 2,2,3,3-Tetrafluoro-3-chloropropionic Acid Methyl Ester; CF3CFClC(O)OCH3; Propanoic acid, 3-chloro-2,2,3,3-tetrafluoro-, methyl ester
EINECS	Contact for details

Quality Control

Our 3-Chlorotetrafluoropropanoic Acid Methyl Ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.2%
Related Substances (GC)	≤ 1.0% total
Density (at 20°C)	~1.5 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.