Description

Tissue Inhibitor-Of Metalloproteinase-2 CAS NO 127497-59-0 is a specific, high-purity recombinant protein that functions as a potent and selective inhibitor of matrix metalloproteinase-2 (MMP-2). This compound matters significantly in biochemical research and therapeutic development due to its critical role in regulating extracellular matrix degradation and tissue remodeling processes. It is primarily needed by biotechnology and pharmaceutical companies, as well as academic research institutions, for applications in cancer research, cardiovascular studies, and the development of treatments for inflammatory and fibrotic diseases.

Application

• Biomedical Research: Used as a key reagent in studies of tumor metastasis, angiogenesis, and tissue repair mechanisms.
• Drug Discovery & Development: Serves as a standard and a tool compound for screening and validating novel MMP-2 inhibitors in pharmaceutical R&D.
• Enzymology Studies: Employed in kinetic assays and functional studies to understand MMP-2 enzyme activity and inhibition profiles.
• Cell Culture & In Vitro Models: Applied in cell-based assays to investigate the role of MMP-2 in cellular invasion, migration, and signaling pathways.
• Therapeutic Protein Development: Investigated for its potential as a therapeutic agent in conditions characterized by excessive matrix degradation, such as arthritis and aneurysms.
• Diagnostic Kit Development: Utilized as a calibrated standard in the development of ELISA kits and other diagnostic assays targeting MMP-2 activity.

Basic Information

Product Name	Tissue Inhibitor-Of Metalloproteinase-2
CAS No.	127497-59-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TIMP-2; TIMP2; Tissue Inhibitor of Metalloproteinases 2; CSC-21K; Fibroblast Collagenase Inhibitor; Metalloproteinase Inhibitor 2; TIMP Metallopeptidase Inhibitor 2
EINECS	Contact for details

Quality Control

Our Tissue Inhibitor-Of Metalloproteinase-2 is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including SDS-PAGE, HPLC, and bioactivity assays, to ensure high purity, correct molecular weight, and functional integrity. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided and available upon request to support your research and development compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or desiccated conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band corresponding to expected molecular weight
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90% of stated mass
Endotoxin Level (LAL)	< 1.0 EU/μg
Biological Activity (MMP-2 Inhibition Assay)	IC50 within specified range per batch
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.